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KMID : 0360419790150010029
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Korean Journal of Pharmacology
1979 Volume.15 No. 1 p.29 ~ p.37
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Experimental Studies on the Vascular Smooth Muscle of Cd²^(+)-poisoned Rabbits
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Abstract
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The tension-length relationships and reactivity of vascular smooth muscle in longitudinal strips from portal vein ana in helical strips from thoracic aorta and pulmonary artery of normotensive control and cadmium-hypertensive rabtits were studied in vitro.
1. The mean arterial pressures of non-poisoned control rabbits was 87.0±4.7 mmHg. However, Cd-poisoned group revealed the significant increase in pressure by 109.04±2.8 mmHg (p<0. 005).
2. By tension-length studies, strips from portal vein of Cd-poisoned group stretched a greater percent increase in length in response to an applied resting force from 0.25 to 5 g than did those from non-poisoned group. On the contrary, strips from thoracic aorta of Cd-poisoned group showed less compliant than those from control, i.e. the former underwent a less percent increase in length than the latter. Passive tension-length relations of pulmonary artery was unaffected by Cd-hypertension.
3. The force of contraction(active tension) was significantly lowered in strips from aorta of Cd-hypertensive group throughout the range of 0.5~2 g passive tension. However, there was no significant difference in the development of active tension of portal vein or pulmonary artery of both groups.
4. The K^(+)-contraction in the portal vein, aorta and pulmonary artery of Cd-poisoned group made no difference in the active force from those of control group.
5. The force of contraction in the strips from aorta of Cd-poisoned group was significanty decreased compared to that of control.
The results suggested that the alterations in vascular reactivity to contracting substances and in distensibility to passive tension were induced in the Cd-hypertensive rabbits.
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